CRP Polyclonal Antibody
Catalogue Numbers: BS60395-50, BS60395-100
Sizes: 50µl, 100µl
Alternative Name: C reactive protein; C reactive protein pentraxin related; C-reactive protein(1-205); CRP; CRP; CRP; MGC88244; Pentraxin 1; PTX 1; PTX1;
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P02741
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Pentraxins, which include C-reactive protein (CRP) and serum amyloid P component (SAP), are prototypic acute phase proteins. CRP and SAP are produced by liver epithelial cells and are characterized by a cyclic pentameric structure and calcium-dependent ligand binding. IL-6 is the major inducer of human CRP gene, and IL-1 and steroids can enhance this induction. Testosterone is required for the expression of CRP transgene in vivo, whereas testosterone is not required for expression of the SAP gene. During the acute-phase response, cytokine C5a acts with IL-6 and/or IL-1b to promote upregulation of the CRP and SAP genes. Both Stat3 and C/EBP are involved in mouse SAP gene expression, but only Stat3 is involved in mouse CRP gene expression. SAP binds to a variety of molecules, including autoantigens and chromatin.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CRP polyclonal antibody detects endogenous levels of CRP protein.
Bioworld Molecular Weight: ~ 25 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of CRP polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: Mouse liver tissue lysate
Lane 3: H9C2 cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human CRP.
Conjugate: Unconjugated
Modification: Unmodified