CRTC3 Monoclonal Antibody - BT-MCA4191

CRTC3 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4191-50, BT-MCA4191-100

Citations, Manuals and MSDS Available upon request.

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Research Areas: Epigenetics and nuclear signaling, Microbiology

Target Protein: CRTC3

Applications: WB, IHC, ICC

Reactivity: Human, Monkey

Clonality: Monoclonal

Clone ID: 5G9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CRTC3

Immunogen: Purified recombinant fragment of human CRTC3 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 68kDa

UniProt Accession: Q6UUV7

Synonyms: TORC3, FLJ21868, CRTC3

GeneID: 64784

Research Use Only