Crystallin-αB (S41) Polyclonal Antibody-BS1738

Crystallin-αB (S41) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1738-50, BS1738-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P02511

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: α-crystallins consist of three gene products, αA, αB and αC-crystallin, which are members of the small heat shock protein family (HSP 20). They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, α-crystallins do not renature these proteins. Expression of αA-crystallin is restricted to the lens. Defects in this gene cause autosomal dominant congenital cataracts (ADCC). The human αB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of αB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Crystallin-αB (S41) pAb in paraffin-embedded human colorectal cancer carcinoma tissue at 1:100.

Bioworld Molecular Weight: ~ 26 kDa

Specificity: Crystallin-αB (S41) polyclonal antibody detects endogenous levels of Crystallin-αB protein.

Alternative Name: Alpha-crystallin B chain; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component; CRYAB; CRYA2; αB-Crystallin

Immunogen: Synthetic peptide, corresponding to amino acids 11-60 of Human Crystallin-αB.

Conjugate: Unconjugated

Modification: Unmodified