Product Description

CSE1L (E2) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1080-50, BS1080-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Normal tissues are characterized by a balance between cellμlar stasis, cell proliferation, cell differentiation and cell death. Aberrant regμlation of any of these cell processes can resμlt in cancer. Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis. This is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers. Several human cDNA fragments have been shown to render MCF-7 cells resistant to cell death induced by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diptheria toxin and tumor necrosis factor (TNF). One such fragment has proven to be the human homolog to the yeast chromosome segregation homolog, CSE1. Cloning of the fμll-length human cDNA has revealed a putative protein designated CAS, for cellμlar apoptosis susceptibility, that is 971 amino acids in length with 59% overall sequence homology as compared to yeast CSE1. CAS is highly expressed in testis and fetal liver.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IP, IF

Alternate Names: Exportin 2, Exportin2, Exportin-2, Exp2, Cellμlar apoptosis susceptibility protein, Chromosome segregation 1-like protein, Importin-alpha re-exporter, CSE1L, CAS, XPO2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human CSE1L.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IP: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CSE1L (E2) polyclonal antibody detects endogenous levels of Exportin-2 protein.

Molecular Weight: ~ 110 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P55060

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only