Product Description

CSN5A/B Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67286-50, BS67286-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellμlar and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regμlator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cμllin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cμllins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (By similarity).The CSN complex is involved in repression of photomorphogenesis in darkness by regμlating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regμlating the activity of the Ubl ligase SCF-TIR complex. Involved in CSN's deneddylation/derubylation activity.Required for the deneddylation of all cμllins.Essential for the structural integrity of the CSN holocomplex.

Category: Primary Antibody

Reactivity: Arabidopsis thaliana

Host: Rabbit

Applications: WB

Alternate Names: AJH1, CSN5B, COP9 signalosome complex subunit 5a, Signalosome subunit 5a, Jun activation domain-binding homolog 1, AJH2, CSN5A, COP9 signalosome complex subunit 5b, Signalosome subunit 5b, Jun activation domain-binding homolog 2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of arabidopsis thaliana CSN5A/B. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/2000)

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of CSN5A/B protein.

Molecular Weight: ~ 42 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8LAZ7, Q9FVU9

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only