CTCF Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA11027-50, RA11027-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: CCCTC-binding factor (CTCF) Homo sapiens This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been Reactivity: Human, Monkey Host: Mouse Applications: WB, ELISA Alternate Names: CTCF, Transcriptional repressor CTCF, 11-zinc finger protein, CCCTC-binding factor, CTCFL paralog Clonality: Monoclonal Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. Storage: -20°C/1 year Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol. Human Gene ID: 10664 Research Use Only