CTNNB1 Monoclonal Antibody - BT-MCA3475

CTNNB1 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3475-50, BT-MCA3475-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Research Areas: Signal Transduction

Target Protein: CTNNB1

Applications: WB, IHC, FCM

Clonality: Monoclonal

Clone ID: 5B6E9

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: CTNNB1

Immunogen: Purified recombinant fragment of human CTNNB1 (AA: 632-781) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide

Molecular Weight (Da): 85.5kDa

UniProt Accession: P35222

Synonyms: CTNNB, MRD19, armadillo

GeneID: 1499

Research Use Only