Product Description

CTPS (K109) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2871-50, BS2871-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CTPS (cytidine-5-prime-triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type-1 domain and is involved in pyrimidine metabolism. CTPS catalyzes the ATP-dependent conversion of UTP to CTP, a rate-limiting reaction that requires either ammonia or L-glutamine as a nitrogen source. Via its catalytic activity, CTPS plays an important role in the synthesis of nucleic acids and is crucial for proper cell growth and development. The function of CTPS is regμlated by a variety of mechanisms, including phosphorylation by protein kinase C (PKC), an event that can either stimμlate or inhibit CTPS activity. The gene encoding CTPS is located in a region on chromosome 1 that is often associated with the progression of several tumor types, suggesting a possible role for CTPS in tumorigenesis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: CTP synthase 1, CTP synthetase 1, UTP--ammonia ligase 1, CTPS1, CTPS

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human CTPS.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CTPS (K109) polyclonal antibody detects endogenous levels of CTPS protein.

Molecular Weight: ~ 67 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17812

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only