Product Description

CTPS (K109) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS2871-50, BS2871-100

Sizes: 50µl, 100µl

Swiss-Prot: P17812

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

Background: CTPS (cytidine-5-prime-triphosphate synthase) is a 591 amino acid protein that contains one glutamine amidotransferase type-1 domain and is involved in pyrimidine metabolism. CTPS catalyzes the ATP-dependent conversion of UTP to CTP, a rate-limiting reaction that requires either ammonia or L-glutamine as a nitrogen source. Via its catalytic activity, CTPS plays an important role in the synthesis of nucleic acids and is crucial for proper cell growth and development. The function of CTPS is regulated by a variety of mechanisms, including phosphorylation by protein kinase C (PKC), an event that can either stimulate or inhibit CTPS activity. The gene encoding CTPS is located in a region on chromosome 1 that is often associated with the progression of several tumor types, suggesting a possible role for CTPS in tumorigenesis.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CTPS (K109) polyclonal antibody detects endogenous levels of CTPS protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CTPS (K109) pAb at 1:1000 dilution
Lane 1: The Kidney tissue lysate of Mouse (40ug)
Lane 2: The Kidney tissue lysate of Rat (40ug)
Lane 3: HEK293T whole cell lysate (10ug)
Lane 4: A549 whole cell lysate (10ug), Immunohistochemistry (IHC) analyzes of CTPS (K109) pAb in paraffin-embedded liver cancer tissue at 1:100.

Bioworld Molecular Weight: ~ 67 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1; CTPS1; CTPS

Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human CTPS.

Conjugate: Unconjugated

Modification: Unmodified