Product Description

Cullin 5 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10782-50, MB10782-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q93034

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cullin 5/CUL5 in C6, 3T3, HelaLysates using Cullin 5 antibody.

Bioworld Molecular Weight: Calculated MW: 91 kDa; Observed MW: 91 kDa

Specificity: IgG

Alternative Name: CUL-5; VACM1; VACM-1

Immunogen: Recombinant protein of human Cullin 5

Conjugate: Unconjugated

Modification: Unmodified