Product Description

CXCL12/SDF1 Polyclonal Antibody

Sizes: 50μL, 100μL, 200μL

Catalogue Numbers: E-AB-40578-50, E-AB-40578-100, E-AB-40578-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CXCL12

Target Synonym: Cxcl12; SDF-1

Research Areas: Immunology,Microbiology,Cardiovascular

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9QZD1

Background: The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12α and SDF1/CXCL12β) that have different properties and biological activities. Additional isoforms of SDF1/CXCL12 have been reported.

Concentration: 1mg/mL

Immunogen: Recombinant Rat CXCL12 protein expressed by E.coli.

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

Purification Method: Antigen Affinity Purification

Dilution: WB: 1:2000-4000

Calculated MW: 10kDa

Observed MW: 10kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only