Product Description

CXCR7 (A356) Polyclonal Antibody

Catalogue Numbers: BS2694-50, BS2694-100

Sizes: 50µl, 100µl

Alternative Name: C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1; CXCR 7; CMKOR1; GPR159; RDC1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P25106

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC, IF

All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Background: Members of the C-X-C or α chemokine family are characterized by a pair of cysteine residues separated by a single amino acid and primarily function as chemoattractants for neutrophils. The C-X-C family includes IL-8, NAP-2, MSGA and stromal cell derived factor-1 (SDF-1). Receptors for the C-X-C family are G protein-coupled, seven pass transmembrane domain proteins and include proteins such as IL-8RA, IL-8RB, CXCR-3 and fusin (also designated LESTR or CXCR-4). C-X-C chemokine receptor type 7 (CXCR-7), also known as RDC-1, is a 362 amino acid receptor for SDF-1. Initially identified as a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor. CXCR-7, with CSCR-4, also acts as a co receptor for human immunodeficiency viruses (HIV). Highly expressed in monocytes, B cells and basophils, and highly active in various biological processes, including cell growth, cell adhesion and tumor growth, CXCR-7 may play a role in tumorigenesis.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CXCR7 (A356) polyclonal antibody detects endogenous levels of CXCR7 protein.

Bioworld Molecular Weight: ~ 41 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CXCR7 (A356) pAb at 1:500 dilution
Lane 1: HEK293T whole cell lysate(40ug)
Lane 2: Panc1 whole cell lysate(40ug)
Lane 3: C0S-7 whole cell lysate(40ug)
Lane 4: U-87MG whole cell lysate(40ug)
Lane 5: K562 whole cell lysate(40ug)
Lane 6: BV2 whole cell lysate(40ug)
Lane 7: PC12 whole cell lysate(40ug)
Lane 8: CT26 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 325-375 of Human CXCR7.

Conjugate: Unconjugated

Modification: Unmodified