Product Description

Cyclin B3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60305-50, BS60305-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regμlatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regμlatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regμlated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regμlatory subunit fluctuates depending on the stage of the cell cycle, thereby regμlating kinase activity. Cyclin B3, also known as CCNB3 or CYCB3, is a 1, 395 amino acid nuclear protein that belongs to the cyclin family of regμlatory proteins. Expressed in testis with lower expression in a variety of other tissues, cyclin B3 is thought to be required for early meiotic prophase I, playing an important role in the meiotic cell cycle. Three isoforms of cyclin B3 exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF/ICC

Alternate Names: Cyclin B3, CyclinB3, G2/mitotic-specific cyclin-B3, CCNB3, CYCB3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin B3.

Dilution: WB: 1:500~1:1000
IF/ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cyclin B3 polyclonal antibody detects endogenous levels of Cyclin B3 protein.

Molecular Weight: ~ 158 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8WWL7

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only