Product Description

Cyclin D1 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65502-50, BS65502-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regμlators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regμlatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regμlated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC-P

Alternate Names: CyclinD1, Cyclin-D1, B cell ccl/lymphoma 1, B cell leukemia 1, B-cell CLL/lymphoma 1, B-cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL1, BCL1 oncogene, CCND 1, CCND1, CCND1 protein, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, included, Parathyroid adenomatosis 1, PRAD1, FSTL3, CCND1_HUMAN, AI327039, B cell lymphoma 1 protein, BCL 1, BCL-1, BCL-1 oncogene, BCL1 oncogene, CCND1/FSTL3 fusion gene, included, cD1, Cyl 1, D11S287E, G1/S specific cyclin D1, G1/S-specific cyclin-D1.

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant human Cyclin D1 protein, around C-terminal 150aa:

Dilution: WB=1:500-2000 IHC-P=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations shoμld be determined by the end user.

Purification: affinity purified by Protein A

Specificity: Cyclin D1 monoclonal Antibody detects endogenous levels of Cyclin D1 protein.

Molecular Weight: ~34 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P25322

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only