Cyclin D1 (Phospho Ser90) rabbit pAb - ES20156

Cyclin D1 (Phospho Ser90) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20156-50, ES20156-100

Citations, Manuals and MSDS Available upon request.

Background: disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t (11; 14) (q13; q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle., disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11; 14) (q13; q32) with the IgH locus., disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t (11; 11) (q13; p15) with the parathyroid hormone (PTH) enhancer., function:Essential for the control of the cell cycle at the G1/S (start) transition., online information:The Singapore human mutation and polymorphism database, PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest., PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex., similarity:Belongs to the cyclin family., similarity:Belongs to the cyclin family. Cyclin D subfamily., subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.,

Alternate Name: G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene)

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from human Cyclin D1 (Phospho Ser90)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 33kD

Human Gene ID: 595

Human SWISS Prot NO: P24385

Subcellular Location: Nucleus. Cytoplasm. Nucleus membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

Research Use Only