Cyclin H Monoclonal Antibody-MB10791

Cyclin H Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10791-50, MB10791-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P51946

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cyclin H in JurkatLysates using Cyclin H antibody.

Bioworld Molecular Weight: Calculated MW: 38 kDa; Observed MW: 38 kDa

Specificity: IgG

Alternative Name: CCNH; Cyclin-H; MO15-associated protein; p34; p37

Immunogen: A synthetic peptide of human Cyclin H

Conjugate: Unconjugated

Modification: Unmodified