Cyclin H Monoclonal Antibody-MB11988

Cyclin H Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11988-50, MB11988-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P51946

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 38 kDa; Observed MW: 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunocytochemistry analysis of Cyclin H in Hela using Cyclin H antibody, and DAPI., Western blot analysis of Cyclin H/p34 in 3T3 lysates using Cyclin H/p34 antibody., Western blot analysis of Cyclin H/p34 in U251, HL-60, Lncap lysates using Cyclin H/p34 antibody

Alternative Name: CCNH; Cyclin-H; MO15-associated protein; p34; p37

Immunogen: A synthetic peptide of human Cyclin H/p34

Conjugate: Unconjugated

Modification: Unmodified