Product Description

Cyclin H Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11035-50, RA11035-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cyclin H (CCNH) Homo sapiens The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple t

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Mouse

Applications: WB

Alternate Names: CCNH, Cyclin-H, MO15-associated protein, p34, p37

Clonality: Monoclonal

Dilution: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.

Storage: -20°C/1 year

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Human Gene ID: 902

Research Use Only