Cyclooxygenase 2 Monoclonal Antibody-MB10757

Cyclooxygenase 2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10757-50, MB10757-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P35354

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC-P

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100

Background: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 69 kDa; Observed MW: 69 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of COX2/cyclooxygenase2 in rat Brain lysates using Cyclooxygenase 2 antibody., Immunohistochemistry analysis of paraffin-embedded Human lung cancer using COX2 antibody. High-pressure and temperature Sodium Citrate pH 6. 0 was used for antigen retrieval.

Alternative Name: COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS

Immunogen: A synthetic peptide of human COX2

Conjugate: Unconjugated

Modification: Unmodified