Product Description

CYFIP1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10795-50, MB10795-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q7L576

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1/500-1/1000

Background: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA . Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes . May act as an invasion suppressor in cancers.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of CYFIP1 in K562, rat Brain, C6, 3T3, HelaLysates using CYFIP1 antibody.

Bioworld Molecular Weight: Calculated MW: 145 kDa; Observed MW: 145 kDa

Specificity: IgG

Alternative Name: SHYC; SRA1; SRA-1; P140SRA-1

Immunogen: A synthetic peptide of human CYFIP1

Conjugate: Unconjugated

Modification: Unmodified