CYFIP2 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA23953-50, RA23953-100
Citations, Manuals and MSDS Available upon request.
Background: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level) .,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB 1:500-2000, ELISA 1:10000-20000
Alternative Names: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse; Rat
GeneID (Human): 26999
Protein MW (KDa): 150+45
SWISS: Q96F07
Source: Rabbit
Research Use Only