Product Description

CYFIP2 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA23953-50, RA23953-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level)., function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA., induction:By p53., RNA editing:Partially edited. Editing appears to be brain-specific., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus., subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

Clonality: Polyclonal

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Molecular Weight: 150+45

Protein Molecular Weight (kDa): 150+45

Storage: -20°C/1 year

Human Gene ID: 26999

Human SwissProt Number: Q96F07

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only