CYFIP2 rabbit pAb - ES8500

CYFIP2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8500-50, ES8500-100

Citations, Manuals and MSDS Available upon request.

Background: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level)., function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA., induction:By p53., RNA editing:Partially edited. Editing appears to be brain-specific., similarity:Belongs to the CYFIP family., subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus., subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,

Alternate Name: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 150+45kD

Human Gene ID: 26999

Human SWISS Prot NO: Q96F07

Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118).

Research Use Only