Product Description

CYP17A1 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0132-50, MB0132-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P05093

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB: 1:1000

Background: CYP17A (17α-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α-hydroxylation and the 17,20-lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension.Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of CYP17A1 and does not cross-react with related proteins.

Bioworld Molecular Weight: Predicted band size: 57KDa
Observed band size: 57KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western BlotDetection of CYP17A1 antibody in Hela, HepG2 and A549 cell lysates using CYP17A1 antibody (1:1000 diluted).

Alternative Name: Steroid 17-alpha-hydroxylase/17,20 lyase; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase; CYP17A1; CYP17; S17AH

Immunogen: Recombinant full length Human CYP17A1.

Conjugate: Unconjugated

Modification: Unmodified