CYP1A1/2 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA23962-50, RA23962-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: cytochrome P450 family 1 subfamily A member 1 (CYP1A1) Homo sapiens This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016], Reactivity: Human, Mouse, Rat, Monkey Host: Rabbit Applications: WB, IHC-p, IF/ICC, ELISA Alternate Names: CYP1A1, Cytochrome P450 1A1, CYPIA1, Cytochrome P450 form 6, Cytochrome P450-C, Cytochrome P450-P1, CYP1A2, Cytochrome P450 1A2, CYPIA2, Cytochrome P (3)450, Cytochrome P450 4, Cytochrome P450-P3 Clonality: Polyclonal Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. Molecular Weight: 58 Protein Molecular Weight (kDa): 58 Storage: -20°C/1 year Human Gene ID: 1543/1544 Human SwissProt Number: P04798/P05177 Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Research Use Only