Product Description

CYP26C1 Polyclonal Antibody

Catalogue Numbers: BS61083-50, BS61083-100

Sizes: 50µl, 100µl

Alternative Name: Cytochrome P450 26C1 (EC:1.14.-.-); CYP26C1

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q6V0L0

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: Cytochrome P450 proteins are heme-thiolate monooxygenases that mediate NADPH-dependent electron transport and function to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Specifically, cytochrome P450s are responsible for metabolizing arachidonic acid to hydroxyeicosatetraenoic acid (a regulator of blood pressure) and epoxyeicosatrienoic acid (a molecule involved in signaling events). CYP26C1 (cytochrome P450, family 26, subfamily C, polypeptide 1) is a 522 amino acid single-pass membrane protein expressed in most tissues at very low levels. Belonging to the cytochrome P450 family, CYP26C1 uses heme groups as cofactors and is induced by retinoic acid. CYP26C1 participates in the retinoic metabolism and acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer, 9-cis-RA.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CYP26C1 polyclonal antibody detects endogenous levels of CYP26C1 protein.

Bioworld Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CYP26C1 polyclonal antibody at 1:500 dilution Lane 1: HEK293T whole cell lysate
Lane 2: RAW264.7 whole cell lysate
Lane 3: H9C2 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human CYP26C1.

Conjugate: Unconjugated

Modification: Unmodified