Product Description

CYP27A1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-11121-60, E-AB-11121-120, E-AB-11121-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: CYP27A1

Target Synonym: 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha; 5-beta-cholestane-3-alpha; 7-alpha; 12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha; 7-alpha; 12-alpha-triol 27-hydroxylase; 5-beta-cholestane-3-alpha; 7-alpha; 12-alpha-triol 27-hydroxylase; 7-alpha; Cholestanetriol 26 monooxygenase; CP27; CP27A; CTX; CYP; CYP27; CYP27A1; Cytochrome P 450C27/25; Cytochrome P-450C27/25; Cytochrome P450 27; Cytochrome P450 27 mitochondrial; Cytochrome P450 family 27 subfamily A member 1; Cytochrome P450 family 27 subfamily A polypeptide 1; Cytochrome P450 subfamily XXVIIA (steroid 27-hydroxylase cerebrotendinous xanthomatosis) polypeptide 1; mitochondrial; Sterol 26 hydroxylase; Sterol 26 hydroxylase mitochondrial; Sterol 26-hydroxylase; Sterol 27 hydroxylase; Sterol 27-hydroxylase; Vitamin D(3) 25 hydroxylase; Vitamin D(3) 25-hydroxylase

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q02318

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease.

Concentration: 0.6 mg/mL

Immunogen: Recombinant protein of human CYP27A1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only