Product Description

CYP2A7 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5683-50, BS5683-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze reactions involved in both drug metabolism and in the synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies, such as CYP1A and CYP2A, based on their sequence similarities. CYP2A7 (cytochrome P450 2A7), also known as CPA7, CPAD, CYPIIA7 or P450-IIA4, is a 494 amino acid peripheral membrane protein that belongs to the CYP2A subfamily of cytochrome P450 proteins. Localized to the endoplasmic reticμlum, CYP2A7 can be induced to high levels in liver in response to foreign compounds, such as carcinogens, pesticides and drugs. CYP2A7 functions as a hydroxylase that uses a heme group to catalyze the oxidation of target flavoproteins.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, ICC

Alternate Names: Cytochrome P450 2A7, CYPIIA7, Cytochrome P450 IIA4

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 435-480 of Human CYP2A7.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CYP2A7 polyclonal antibody detects endogenous levels of CYP2A7 protein.

Molecular Weight: ~ 56 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P20853

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only