Product Description

CYP2B6 (H271) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2403-50, BS2403-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P20813

Host: Rabbit

Reactivity: Human

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: CYP2B6 (cytochrome P450 2B6) is a 491 amino acid protein encoded by the human gene CYP2B6. CYP genes are highly polymorphic and can affect individual drug response and adverse reactions to a great extent. The CYP2B6 gene product, along with a few other CYP gene products, are highly susceptible to variation due to several copy number variants (CNV), missense mutations, insertions and deletions, and gene expression mutations. There are 57 active CYP genes and 58 pseudogenes known in the human genome. In liver microsomes, CYP2B6 is involved in an NADPH-dependent electron transport pathway. It acts to oxidize a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. CYP2B6 is expressed in liver, lung and heart and can be induced by phenobarbital.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of CYP2B6 (H271) pAb in paraffin-embedded human liver cancer tissue.

Bioworld Molecular Weight: ~ 56 kDa

Specificity: CYP2B6 (H271) polyclonal antibody detects endogenous levels of CYP2B6 protein.

Alternative Name: CYP 2B6; CYP IIB6; CYP2B6; Cytochrome P450 2B6; Cytochrome P450 family 2 subfamily B polypeptide 6; P450;

Immunogen: Synthetic peptide, corresponding to amino acids 250-300 of Human CYP2B6.

Conjugate: Unconjugated

Modification: Unmodified