Product Description

CYP2J2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5687-50, BS5687-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CYP2J2 (cytochrome P450 2J2), also known as CPJ2, is a member of the cytochrome P450 protein superfamily. Localized to the ER (endoplasmic reticμlum) and microsomal membranes, CYP2J2 is one of three cytochrome P450 enzymes that are responsible for metabolizing arachidonic acid to epoxyeicosatrienoic acids. Functioning via an NADPH-dependent olefin epoxidation, CYP2J2 epoxidizes endogenous cardiac arachidonic acid pools to four different isoforms of epoxyeicosatrienoic acid, all of which are important regμlators of cardiovascμlar homeostasis and vascμlar tone. CYP2J2 is highly expressed in the heart with low levels of expression found in the liver, colon and kidneys. Up-regμlation of CYP2J2 by a c-Jun responsive pathway is thought to promote the neoplastic phenotype of certain carcinoma cells, implicating CYP2J2 in carcinogenesis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, ICC

Alternate Names: Cytochrome P450 2J2, Arachidonic acid epoxygenase, CYPIIJ2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 270-315 of Human CYP2J2.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
ICC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: CYP2J2 polyclonal antibody detects endogenous levels of CYP2J2 protein.

Molecular Weight: ~ 57 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P51589

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only