Product Description

CYP2R1 Polyclonal Antibody

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Sizes: 50µl, 100µl

Catalogue Numbers: BS65875-50, BS65875-100

Swiss-Prot: Q6VVX0

Host: Rabbit

CYP2R1 Polyclonal Antibody-BS65875

Storage and Stability: Store at 4°C short term. Aliquot and store at -48°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,

Applications: WB,

All Applications: WB=1:500-2000

Background: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.

Purification and Purity: affinity purified by Protein A

Specificity: CYP2R1 Polyclonal Antibody detects endogenous levels of CYP2R1 protein.

Bioworld Molecular Weight: ~53kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Primary: Anti-CYP2R1 at 1/1000 dilution, Primary: Anti- CYP2R1 at 1/1000 dilution

Alternative Name: Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.

Immunogen: KLH conjugated synthetic peptide derived from human CYP2R1:251-350/501

Modification: Unmodified

Conjugate: Unconjugated