CYP4X1 (V273) Polyclonal Antibody-BS3023

CYP4X1 (V273) Polyclonal Antibody

Catalogue Numbers: BS3023-50, BS3023-100

Sizes: 50µl, 100µl

Alternative Name: Cytochrome P450 4X1; CYPIVX1; UNQ1929; PRO4404

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q8N118

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200

Background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The CYP4X1 gene product has been provisionally designated CYP4X1 pending further characterization.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CYP4X1 (V273) polyclonal antibody detects endogenous levels of CYP4X1 protein.

Bioworld Molecular Weight: ~ 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CYP4X1 (V273) pAb at 1:1000 dilution
Lane 1: CT26 whole cell lysate(40ug)
Lane 2: H9C2 whole cell lysate(40ug)
Lane 3: Hela whole cell lysate(40ug)
Lane 4: HEK293T whole cell lysate(40ug)
Lane 5: K562 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 240-292 of Human CYP4X1.

Conjugate: Unconjugated

Modification: Unmodified