Product Description

CYP7A1 Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10596-50, RA10596-100

Citations, Manuals and MSDS Available upon request.

Background: cytochrome P450 family 7 subfamily A member 1 (CYP7A1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010],

Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage Instructions: -20°C/1 year

Applications: WB

Species Cross-Reactivity: Human

GeneID (Human): 1581

SWISS: P22680

Source: Mouse

Research Use Only