Cytochrome P450 1A2 Monoclonal Antibody-MB66805

Cytochrome P450 1A2 Monoclonal Antibody

Catalogue Numbers: MB66805-50, MB66805-100

Sizes: 50µl, 100µl

Product: Mouse IgG3. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P05177

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: CYP1A2, also called cytochrome P450 1A2, is a heme-thiolate monooxygenase enzyme involved in the NADPH-dependent electron transport pathway of liver microsomes. A member of the cytochrome P450 family, CYP1A2 oxidizes fatty acids, steroids and xenobiotics. It is also involved in the metabolism of imiprimine, propranol and clozapine. CYP1A2 localizes to the membrane of the endoplasmic reticulum. It is induced by 3-methylcholanthrene, Insulin, modafinil and hyperforin and inhibited by many fluoroquinolone antibiotics, caffeine, fluvoxamine and cimetidine. In addition, the involvement of CYP1A2 in the metabolism of estrogen is associated with a reduced risk of breast cancer.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Cytochrome P450 1A2 protein.

Extra Notes: Western blot analysis of Cytochrome P450 1A2 expression in SKBR3 (A) whole cell lysates.

Bioworld Molecular Weight: ~ 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Cytochrome P450 1A2; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 1A2. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified