Product Description

Cytochrome P450 1A2 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66805-50, MB66805-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: CYP1A2, also called cytochrome P450 1A2, is a heme-thiolate monooxygenase enzyme involved in the NADPH-dependent electron transport pathway of liver microsomes. A member of the cytochrome P450 family, CYP1A2 oxidizes fatty acids, steroids and xenobiotics. It is also involved in the metabolism of imiprimine, propranol and clozapine. CYP1A2 localizes to the membrane of the endoplasmic reticμlum. It is induced by 3-methylcholanthrene, Insμlin, modafinil and hyperforin and inhibited by many fluoroquinolone antibiotics, caffeine, fluvoxamine and cimetidine. In addition, the involvement of CYP1A2 in the metabolism of estrogen is associated with a reduced risk of breast cancer.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: Cytochrome P450 1A2, CYPIA2, Cytochrome P(3)450, Cytochrome P450 4, Cytochrome P450-P3

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 1A2. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Purification: This antibody is purified through a protein G column.

Specificity: Recognizes endogenous levels of Cytochrome P450 1A2 protein.

Molecular Weight: ~ 72 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P05177

Product: Mouse IgG3. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only