Product Description

Cytochrome P450 2C9 Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66867-50, MB66867-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids . Mechanistically, uses molecμlar oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecμle, with two electrons provided by NADPH via cytochrome P450 reductase.Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids.Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regμlator of cellμlar cholesterol homeostasis .Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 .Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids .Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol .Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan .

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: CYP2C10, Cytochrome P450 2C9, (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC9, Cytochrome P-450MP, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, S-mephenytoin 4-hydroxylase

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Cytochrome P450 2C9. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/1000)

Specificity: Recognizes endogenous levels of Cytochrome P450 2C9 protein.

Molecular Weight: ~ 55 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P11712

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only