Cytokeratin 1 Polyclonal Antibody-BS90373

Cytokeratin 1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90373-50, BS90373-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P04264(Human) P04104(Mouse) Q6IMF3(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:1,000
IHC:1:100-1:500

Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Cytokeratin 1 polyclonal antibody detects endogenous levels of Cytokeratin 1 protein.

Bioworld Molecular Weight: 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cytokeratin 1 on different lysates using anti-Cytokeratin 1 antibody at 1/1,000 dilution.
Positive control:
Lane 1: 293T
Lane 2: Hela, Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-Cytokeratin 1 antibody. Counter stained with hematoxylin.

Alternative Name: CK-1, K1, KRT1, 67 kDa cytokeratin, CK-1, CK1, Cytokeratin-1, Cytokeratin1, EHK, EHK1, Epidermolytic hyperkeratosis 1, EPPK, Hair alpha protein, K1, K2C1, Keratin, Keratin type II cytoskeletal 1, Keratin-1, Keratin1, KRT 1, Krt1, KRT1A, NEPPK, type II cytoskeletal 1, Type II keratin Kb1, Type-II keratin Kb1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified