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Cytokeratin 13 Polyclonal Antibody-BS90375

Cytokeratin 13 Polyclonal Antibody-BS90375

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Cytokeratin 13 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90375-50, BS90375-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P13646(Human) P08730(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, zebrafish

Applications: WB, ICC IHC

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Cytokeratin 13 polyclonal antibody detects endogenous levels of Cytokeratin 13 protein.

Bioworld Molecular Weight: 50 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Cytokeratin 13 on human lung lysates using anti-Cytokeratin 13 antibody at 1/1,000 dilution., ICC staining Cytokeratin 13 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CK-13, K13, KRT13, 47 kDa cytokeratin, CK-13, CK13, Cytokeratin 13, Cytokeratin-13, K13, K1C13, Ka13, Keratin 13, Keratin, keratin type I cytoskeletal 13, Keratin-13, Krt-1.13, Krt1-13, KRT13, MGC161462, MGC3781, type I cytoskeletal 13, Type I keratin Ka13, WSN2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified