Product Description

Cytokeratin 14/16 (S5) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1200-50, BS1200-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. Mutations in the gene encoding human Cytokeratin 14 lead to epidermolysis bμllosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Keratin, type I cytoskeletal 14, Cytokeratin-14, Short name=CK-14, Keratin-14, Short name=K14, KRT14, CK-14, CK 14, CK14, Cytokeratin-14, Cytokeratin 14, Cytokeratin14, Keratin, type I cytoskeletal 16, Cytokeratin-16, Short name=CK-16, Keratin-16, Short name=K16, KRT16, KRT16A, CK-16, CK 16, CK16, Cytokeratin-16, Cytokeratin 16, Cytokeratin16,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human Cytokeratin 14

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Cytokeratin 14/16 (S5) polyclonal antibody detects endogenous levels of Cytokeratin 14 and Cytokeratin 16 protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P02533

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only