Cytokeratin 15 Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB65999-50, MB65999-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bμlge and may be a usefμl marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicμlar differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodμlar basal cell carcinoma, sometimes rendering a diagnosis difficμlt. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins. Category: Primary Antibody Reactivity: Human Host: Mouse Applications: WB, IHC Alternate Names: KRTB, Keratin type I cytoskeletal 15, Cytokeratin-15, CK-15, Keratin-15, K15 Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Cytokeratin 15. The exact sequence is proprietary. Dilution: WB (1/500 - 1/1000), IHC (1/100 - 1/300) Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: Recognizes endogenous levels of Cytokeratin 15 protein. Molecular Weight: ~ 49 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P19012 Product: Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide. Research Use Only