Cytokeratin 16 Monoclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: MB66000-50, MB66000-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also usefμl markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN). Category: Primary Antibody Reactivity: Human Host: Mouse Applications: IHC Alternate Names: KRT16A, Keratin type I cytoskeletal 16, Cytokeratin-16, CK-16, Keratin-16, K16 Clonality: Monoclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Cytokeratin 16. The exact sequence is proprietary. Dilution: IHC (1/100 - 1/300) Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: Recognizes endogenous levels of Cytokeratin 16 protein. Molecular Weight: ~ 51 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P08779 Product: Mouse IgG. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide. Research Use Only