D4DR (L396) Polyclonal Antibody-BS3160

D4DR (L396) Polyclonal Antibody

Catalogue Numbers:BS3160-50, BS3160-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P21917

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC, IF

All Applications: IHC: 1:50~1:200
IF: 1:50~1:200

Background: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.DRD4 expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 48 kDa

Specificity: D4DR (L396) polyclonal antibody detects endogenous levels of D4DR protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: D(4) dopamine receptor; D(2C) dopamine receptor; Dopamine D4 receptor; DRD4

Immunogen: Synthetic peptide, corresponding to amino acids 370-420 of Human D4DR.

Conjugate: Unconjugated

Modification: Unmodified