DAAM1 rabbit pAb - ES8614

DAAM1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8614-50, ES8614-100

Citations, Manuals and MSDS Available upon request.

Background: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct

Alternate Name: Disheveled-associated activator of morphogenesis 1

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000, ELISA 1:10000-20000

Reactivity: Human; Mouse

Immunogen: Synthetic peptide from human protein at AA range: 400-500

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 123kD

Human Gene ID: 23002

Human SWISS Prot NO: Q9Y4D1

Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Perinuclear.

Research Use Only