Dab1 (Q226) Polyclonal Antibody-BS3646

Dab1 (Q226) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3646-50, BS3646-100

Sizes: 50µl, 100µl

Swiss-Prot: O75553

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IF

Background: Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Dab1 (Q226) polyclonal antibody detects endogenous levels of Dab1 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Dab1 (Q226) pAb at 1:500 dilution
Lane 1: MCF-7 whole cell lysate (40ug)
Lane 2: Hela whole cell lysate (40ug)
Lane 3: SGC7901 whole cell lysate (40ug)
Lane 4: PC12 whole cell lysate (40ug)
Lane 5: The Brain tissue lysate of Mouse (40ug), Immunohistochemistry (IHC) analyzes of Dab1 (Q226) pAb in paraffin-embedded human small intestine tissue at 1:100.

Bioworld Molecular Weight: ~ 60-72 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Disabled homolog 1; DAB1

Immunogen: Synthetic peptide, corresponding to amino acids 201-250 of Human Dab1.

Conjugate: Unconjugated

Modification: Unmodified