DAB2 Monoclonal Antibody-MB11993

DAB2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11993-50, MB11993-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P98082

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-P, IP,

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 82 kDa; Observed MW: 96 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of DAB2 in HepG2, U2OS, U251 lysates using DAB2 antibody., Immunohistochemistry analysis of paraffin-embedded Human lung cancer using DAB2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: DOC2; DOC-2

Immunogen: A synthetic peptide of human DAB2

Conjugate: Unconjugated

Modification: Unmodified