DAB2 Monoclonal Antibody-MB11994

DAB2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11994-50, MB11994-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P98082

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, ICC/IF, IP,

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 82 kDa; Observed MW: 96 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of DAB2 in Hela, A549, HL-60, U2OS, C6 lysates using DAB2 antibody., Immunocytochemistry analysis of DAB2 in hela using DAB2 antibody, and DAPI

Alternative Name: DOC2; DOC-2

Immunogen: A synthetic peptide of human DAB2

Conjugate: Unconjugated

Modification: Unmodified