DAB2 Polyclonal Antibody - E-AB-14925

DAB2 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-14925-60, E-AB-14925-120, E-AB-14925-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: DAB2

Target Synonym: DAB 2; Dab; mitogen-responsive phosphoprotein; homolog 2 (Drosophila); DAB2; Differentially expressed in ovarian cancer 2; Differentially expressed protein 2; Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); Disabled homolog 2; Disabled homolog 2 mitogen responsive phosphoprotein (Drosophila); Disabled homolog 2 mitogen responsive phosphoprotein; Disabled; Drosophila; homolog of; 2; DOC 2; DOC2; FLJ26626; Mitogen responsive phosphoprotein

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P98082

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.6 mg/mL

Immunogen: Recombinant protein of human DAB2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Calculated MW: 82kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only