DAB2 Rabbit Polyclonal Antibody - BT-AP08887

DAB2 Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08887-20, BT-AP08887-50, BT-AP08887-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells| but is down-regulated or absent from ovarian carcinoma cell lines| suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2| an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras)| via its C-terminal proline-rich sequences| and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Areas: Epigenetics and nuclear signaling; Signal transduction

Target Protein: DAB2

Applications: WB

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: DAB2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P98082; Mouse: P98078; Rat: O88797

Synonyms: DAB2; Disabled homolog 2; DOC-2; Differentially-expressed protein 2)

GeneID: Human: 1601; Mouse: 13132; Rat: 79128

Research Use Only