DAB2 Rabbit Polyclonal Antibody - RA31915

DAB2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA31915-50, RA31915-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.333% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 1601

Protein MW (KDa): 85

SWISS: P98082

Source: Rabbit

Research Use Only