Product Description

DAB2 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA31915-50, RA31915-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)

Clonality: Polyclonal

Dilution: WB 1:500-2000

Molecular Weight: 85

Protein Molecular Weight (kDa): 85

Storage: -20°C/1 year

Human Gene ID: 1601

Human SwissProt Number: P98082

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.333% sodium azide.

Research Use Only