DAPK1 (phospho-S736) Polyclonal Antibody-BS64196

DAPK1 (phospho-S736) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS64196-50, BS64196-100

Sizes: 50µl, 100µl

Swiss-Prot: P53355

Host: Rabbit

Reactivity: Human

Applications: IHC

Background: DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase (DAPK) contains a “death domain” and has been shown to mediate IFN-γ-induced apoptosis. The introduction of DAPK into highly metastatic carcinoma clones lacking DAPK expression has been shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis. ZIP kinase contains a leucine zipper domain, which is necessary for homodimerization and for interaction with other leucine zipper proteins. ZIP kinase dimerizes with ATF-4, an ATF/CREB transcription factor family member that contains a leucine zipper. Overexpression of ZIP kinase has been shown to result in morphological changes associated with apoptosis in NIH/3T3 cells.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: DAPK1 (phospho-S736) polyclonal antibody detects endogenous levels of DAPK1 protein only when phosphorylated at Ser736.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of DAPK1 (phospho-S736) polyclonal antibody in paraffin-embedded human liver cancer tissue at 1:50.

Bioworld Molecular Weight: ~ 160 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: DAK1;
DAP K1;
DAP kinase 1;
DAPK 1;
DAPK;
DAPK1;
DAPK1_HUMAN;
Death Associated Protein Kinase 1;
Death-associated protein kinase 1;

Immunogen: Synthetic phosphopeptide derived from human DAPK1 around the phosphorylation site of Ser736.

Conjugate: Unconjugated

Modification: Phosphorylation