Daxx Monoclonal Antibody
Size: 50μL, 100μL
Catalogue Numbers: RA11082-50, RA11082-100
Citations, Manuals and MSDS Available upon request.
Background: death domain associated protein (DAXX) Homo sapiens This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript varian
Condition: Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Storage Instructions: -20°C/1 year
Applications: WB; IF/ICC; FCM; ELISA
Species Cross-Reactivity: Human
GeneID (Human): 1616
SWISS: Q9UER7
Source: Mouse
Research Use Only