Product Description

Dbf4 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA24110-50, RA24110-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: function:Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle., induction:Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 DBF4-type zinc finger., similarity:Contains 2 BRCT domains., subunit:Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2L, ORC4L and ORC6L., tissue specificity:Highly expressed in testis and thymus. Expressed also in most cancer cells lines.,

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Applications: WB, IHC-p, IF (paraffin section), ELISA

Alternate Names: DBF4, ASK, DBF4A, ZDBF1, Protein DBF4 homolog A, Activator of S phase kinase, Chiffon homolog A, DBF4-type zinc finger-containing protein 1

Clonality: Polyclonal

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight: 77

Protein Molecular Weight (kDa): 77

Storage: -20°C/1 year

Human Gene ID: 10926

Human SwissProt Number: Q9UBU7

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only