Dbf4 rabbit pAb - ES2148

Dbf4 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2148-50, ES2148-100

Citations, Manuals and MSDS Available upon request.

Background: function:Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle., induction:Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 DBF4-type zinc finger., similarity:Contains 2 BRCT domains., subunit:Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2L, ORC4L and ORC6L., tissue specificity:Highly expressed in testis and thymus. Expressed also in most cancer cells lines.,

Alternate Name: DBF4; ASK; DBF4A; ZDBF1; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human DBF4. AA range:10-59

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 77kD

Human Gene ID: 10926

Human SWISS Prot NO: Q9UBU7

Subcellular Location: Nucleus

Research Use Only